Lily Gladstone had proven her acting chops and won critical acclaim in Kelly Reichardt's 2016 indie drama "Certain Women," leading top billing alongside Kristen Stewart, Michelle Williams, and Laura Dern. But it wasn't quite enough career momentum to keep Gladstone from reconsidering her options, and despite making sporadic bit appearances in films and on TV, the actor was seriously considering restarting her life as a data analyst.

That was until, in August 2020, the one and only Martin Scorsese requested a Zoom call with Gladstone for a lead role in his upcoming film "Killers of the Flower Moon." Of course, the rest is history—Gladstone is firmly back in the biz and landed a 2024 Academy Award nomination for her performance in the critically acclaimed blockbuster. She went on to star in the June 2024 Apple TV+ film "Fancy Dance" and in Andrew Ahn's remake of "The Wedding Banquet," which hit theaters in April 2025.

After becoming a veritable action star leading "The Mummy" franchise in the '90s and early 2000s, Brendan Fraser spent years out of the spotlight until reemerging in 2022 to near-universal acclaim for his role in Darren Aronofsky's "The Whale." This absence was no fluke.

After speaking out about being sexually assaulted by the former president of the Hollywood Foreign Press Association in 2003, Fraser claimed he experienced industry blacklisting and deep depression. That, on top of numerous traumatic injuries accrued from working on "The Mummy," kept Fraser from the mainstream and relegated him to a series of overlooked side roles. With "The Whale," Fraser's return to the silver screen led to an inspiring comeback narrative and, ultimately, awards glory as the Best Actor Oscar winner in 2023. The acclaimed actor will next star as Dwight D. Eisenhower in the upcoming movie "Pressure," which started filming in the U.K. in the fall of 2024.

Though he spent his childhood acting in some of the biggest movies of the 1980s—"Indiana Jones and the Temple of Doom," "The Goonies"—Ke Huy Quan found that appearing in major blockbusters wasn't exactly a meal ticket to Hollywood. As an Asian American actor, Quan struggled for years to find his footing before quitting acting to work behind the scenes on films like Wong Kar-Wai's "2046."

Still, shortly after deciding to return to the profession in his late 40s, directors Daniel Kwan and Daniel Scheinert asked him to audition for the role of Waymond Wang in their 2022 film "Everything Everywhere All at Once." Quan received rave reviews and a Best Supporting Actor Oscar for his work in the film and has since appeared in series like "Loki" and "American Born Chinese." Fans most recently saw Quan in the 2025 action-comedy "Love Hurts," and he'll soon star in the thriller "Fairytale in New York." 

During the '80s, Mickey Rourke received praise for his performances in "Barfly" and "Angel Heart," and he led Francis Ford Coppola's "Rumble Fish" and "The Pope of Greenwich Village." However, he later experienced a string of commercial failures, and directors deemed him difficult to work with, so in the 1990s, Rourke quit acting to pursue boxing.

Though his time in the ring unfortunately led to injuries that required extensive facial reconstructive surgery, he began slowly making an acting comeback during the 2000s in films such as "Sin City" and "Domino." In 2008, he starred in Darren Aronofsky's "The Wrestler," earning an Academy Award nomination for Best Actor and a Golden Globe win.

Though she made her mark on pop culture as Stifler's mom in "American Pie," Paulette in "Legally Blonde," and as a frequent collaborator on director Christopher Guest's films, Jennifer Coolidge saw her career flatline for years in a series of less-than-buzzy side roles. But after a friend persuaded her to take on a role in Mike White's "The White Lotus," things quickly turned around for Coolidge.

Her performance as Tanya McQuoid in the first two seasons of the anthology series earned her both Primetime Emmy and a Golden Globe awards, and in her emotional acceptance speech for the latter, she thanked White for helping reignite her career.

Though some may know him best from "Beetlejuice," Michael Keaton Douglas cemented himself as a Hollywood great by taking on the role of Batman in Tim Burton's 1989 and 1992 DC Comics-based films. Keaton continued working on other films during the '90s, including Quentin Tarantino's "Jackie Brown" and Steven Soderbergh's "Out of Sight." However, he was never able to reach the highs of Burton's "Batman" films, and his career took a downturn during the 2000s, when he starred in a number of films to consistently mixed results.

It wasn't until 2014, when Keaton took on the lead role of a washed-up superhero movie star in Alejandro González Iñárritu's "Birdman," that he finally made his grand Hollywood comeback. He went on to star in another Oscar-winning film, "Spotlight," just a year later, and in 2024, he reprised his Beetlejuice character for the long-awaited super-successful sequel, "Beetlejuice Beetlejuice."

Eddie Murphy was once one of the world's most beloved and successful comedic actors, jumping from a stint on "Saturday Night Live" in the '80s to a succession of now-iconic comedy films like "Trading Places," "Coming to America," and "Beverly Hills Cop." But Murphy's career began to decline during the late 1990s, and by the 2000s, Murphy had seemingly swapped adult comedy for family-friendly fare that generated mixed responses from critics and audiences.

Though his role in 2006's "Dreamgirls" did get him an Academy Award nomination for Best Supporting Actor, it was 2019's "Dolemite Is My Name," in which Murphy starred as real-life blaxploitation actor Rudy Ray Moore, that bounced Murphy back into the limelight. The role won him a Golden Globe nomination and propelled him back to a hosting gig on "SNL," which earned him a 2020 Primetime Emmy Award.

Keanu Reeves has been a big name in Hollywood since starring in 1989's "Bill & Ted's Excellent Adventure," a breakout role that catapulted him to '90s fame in "Point Break" and "The Matrix" films. However, he languished in little-seen indies, schlocky action flicks, and a series of commercial failures during the mid-to-late 2000s.

"Sad Keanu" even became a popular internet meme in 2010, still four years shy of Reeves' starring appearance in the first "John Wick" film, which bounced the actor back onto the A-list.

Now, both "John Wick" and Reeves have achieved legendary status—the four-film franchise raked in more than $1 billion at the global box office over nine years, and Reeves has appeared in a number of high-profile pics in the same time period, even reprising his role as Neo in 2021's "The Matrix Resurrections." In December 2024, Reeves saw two more projects debut: "Sonic the Hedgehog 3," in which he plays Shadow, and Prime Video's animated series "Secret Level."

Matthew McConaughey achieved a career breakthrough in the early 1990s, starring as the iconic David Wooderson in Richard Linklater's "Dazed and Confused." But by the 2000s, his career stagnated amid a slew of rom-com leading roles, and McConaughey decided to seek out more challenging, dramatic work. During the 2010s, an era often called "The McConnaissance," McConaughey starred on HBO's "True Detective" series, as well as movies like "The Wolf of Wall Street," "Interstellar," and "Dallas Buyers Club," for which he won an Academy Award.

John Travolta hit it big during the 1970s, with back-to-back classics "Carrie," "Saturday Night Fever," and "Grease." But by the '80s, Travolta's career hit a bit of a standstill. He reteamed with director Brian de Palma for "Blow Out," which was lauded by critics but bombed at the box office, and from there he continued to star in a slew of critical and/or commercial failures.

When a hip, new director named Quentin Tarantino burst onto the Hollywood scene in the early '90s, Travolta's career was granted a second life. Travolta was cast as mobster hitman Vincent Vega in Tarantino's "Pulp Fiction," a performance that brought him back from the acting doldrums and earned him an Academy Award nomination.

Born into the acting dynasty of the Barrymore family, Drew Barrymore began her career as a child actor in flicks like "Firestarter" and "E.T. The Extra-Terrestrial"—but being a "nepo baby" did not necessarily mean Barrymore had it easy. As is often the sad case for child actors, Barrymore had a notoriously fraught, unstable childhood, during which she misused drugs and faced challenges related to her mental health.

She spent time in both rehab and a mental institution as a young teen before becoming emancipated at age 14 from her mostly absent parents. But after getting cleaned up, Barrymore has gone on to enjoy an extremely successful Hollywood career as an adult, from starring in films like "Scream," "The Wedding Singer," and "Charlie's Angels" to now hosting her own talk show.

Although Natasha Lyonne starred in numerous films as a teen actor during the '90s—"But I'm a Cheerleader," "Slums of Beverly Hills," "American Pie"—her promising career floundered for a number of years. While she continued to act, she was dealing with an addiction to heroin, which brought with it a number of life-threatening health issues. However, Lyonne has been clean since 2006, which allowed her to find a later career revival through a role on the popular Netflix series "Orange Is the New Black." This comeback eventually led her to create her own acclaimed series, "Russian Doll," and, more recently, star in Rian Johnson's "Poker Face."

Mandy Moore made it big as a pop singer in the late '90s and early 2000s, rising to fame with her hit single "Candy" in 1999. By the turn of the century, she was dipping her toes into the acting world, debuting in "The Princess Diaries" and breaking hearts everywhere in the romance drama "A Walk to Remember."

However, aside from voicing Rapunzel in Disney's "Tangled," Moore remained mostly overlooked or in supporting parts in the early 2010s, and her films did not often garner critical praise or box-office profits. Moore seemed to struggle to find her second act, but she eventually starred in the NBC melodrama "This Is Us" in 2016, which later garnered her a Golden Globe nomination.

To say that Nicolas Cage had a "comeback" might sound a bit confusing—the guy rarely seems to stop working, partly due to some hefty real estate debts he's accrued over the years. But after leading popular flicks such as "Raising Arizona," "Con Air," and "Face/Off," and being nominated for two Academy Awards (winning one), Cage appeared in numerous universally panned films that tarnished his reputation.

Nicolas Cage memes reigned supreme on the internet during the 2010s, and it seemed the actor's best days might be behind him. However, he experienced something of a career resurgence in 2018 when he starred in the acclaimed indie horror "Mandy," and Cage has continued to restore his standing with roles in independent features such as "Pig" and "Dream Scenario."

It's hard to imagine that a Hollywood icon like Marlon Brando could have ever experienced a career slump, but nevertheless, it happened to the "On the Waterfront" star as he hit middle age. In fact, prior to his career-energizing role of Vito Corleone in Francis Ford Coppola's "The Godfather," Brando was something of a persona non grata in Tinsel Town, as he stumbled through a series of commercial failures and a reputation of being difficult to work with.

Studios were unwilling to take a chance on an actor who seemed to have become box-office poison, and Coppola himself had to fight with "The Godfather" producers in order to secure Brando for the film. That battle led to one of the most pivotal performances in movie history, which won Brando an Academy Award and fully cemented his status as a true Hollywood legend.

Additional writing and story editing by Cu Fleshman. Copy editing by Paris Close.